Two people stand on a grassy hill at sunset in Punta del Este, silhouetted against a colorful sky, with large palm trees framing the scene.
Experts in Tailor-Made

Argentina & Uruguay Combination Trips

20+ Years Designing South America Tours

Argentina and Uruguay tours are easy to combine, offering travelers a seamless way to explore two culturally rich countries in one itinerary. Connected by the Río de la Plata, the capitals of Buenos Aires and Montevideo are just a short ferry journey apart, making multi-country travel simple and efficient. From vibrant cities to historic towns and scenic countryside, Argentina and Uruguay complement each other beautifully.

Highlights Across Argentina and Uruguay

Begin your journey in Buenos Aires, exploring iconic landmarks such as Plaza de Mayo and Casa Rosada, and enjoying world-famous tango shows and Argentine cuisine. Cross into Uruguay to discover charming Colonia del Sacramento, a UNESCO World Heritage Site, or continue to Montevideo for its waterfront rambla, historic neighborhoods, and lively music scene. Wine lovers can explore Argentina’s Mendoza and Cafayate regions alongside vineyards near Montevideo, tasting Malbec, Torrontés, and Tannat along the way. Many travelers also extend their trip to destinations such as Iguazú Falls, Punta del Este, or combine Argentina and Uruguay with Chile or Brazil for a broader South America experience.

Trusted for over 20 years designing tailor-made Argentina travel experiences

Want to explore a single country in more depth? See our full collections of Argentina tours and Uruguay tours for dedicated one-country itineraries.

Argentina & Uruguay Combination Itineraries

  • A bright yellow colonial church with two towers and a detailed baroque entrance stands in a sunlit plaza in South America, with people walking and pigeons near a central fountain under a blue sky—one of the region’s lesser-known world wonders.
    A map of South America highlights a travel route from Lima to Rio de Janeiro, featuring World Wonders like Machu Picchu, with stops in Sacred Valley, Cuzco, and Foz do Iguassu. Icons show overnight stays and excursions along the way.
    Brazil • Bolivia • Peru • South America • Multi-Country • Iguazu Falls • Lima • Cusco • Machu Picchu
  • A wooden cart rests in a field of blooming lupines, with green trees, a lake, and the snow-capped mountains of Patagonia rising in the background—an idyllic scene reminiscent of estancias beneath a partly cloudy sky.
    Popular
    Map of southern Argentina and Chile in Patagonia showing travel routes between El Calafate, El Chaltén, and Los Glaciares. Icons indicate overnights, estancias, and glacier excursions. Inset map highlights the region’s location in South America.
    Cave of the Hands • Perito Moreno Glacier • Argentina • South America • Buenos Aires • El Calafate • Patagonia • Los Glaciares National Park
  • Aerial view of a city with a park-lined avenue leading to a domed landmark at sunset, surrounded by densely packed buildings under a colorful sky—a scene reminiscent of the Tucuman-Buenos Aires Railway journey.
    A map showing a travel route between Buenos Aires, Argentina, and Uruguay’s Montevideo, with stops at Colonia and El Tigre. Icons mark overnights and excursions, while an inset highlights the vibrant rhythm of this South American region.
    Argentina • Uruguay • South America • Multi-Country • Buenos Aires • Patagonia • Montevideo • Punta del Este
  • A sandy beach with large rocky formations, palm trees, and grass next to calm blue water under a bright, clear sky. Buildings of Punta del Este are visible in the far distance across the water.
    Map of southeastern Uruguay showing travel routes for a Montevideo trip, with stops at Punta del Este, Cabo Polonio, Aigua, Cebollatí, and Quebrada de los Cuervos—ideal for a bird watching tour with detailed excursion and overnight locations.
    Uruguay • Montevideo • Punta del Este
  • Aerial view of a cityscape with a tall clock tower in a park, large historic railway station behind it, green trees, and glimpses of lakes, people, and city buildings extending into the distance under a partly cloudy sky.
    Popular
    Iguazu Falls • Perito Moreno Glacier • Argentina • Buenos Aires • El Calafate • Patagonia
  • Snow-capped jagged mountains rise behind a rocky foreground and a turquoise lake near El Chalten, under a bright blue sky with scattered clouds—a breathtaking view on any Patagonia Eco Tour.
    Map of southern Argentina highlighting Los Glaciares National Park. Key locations include El Calafate and El Chaltén, with icons for overnights, excursions, and Patagonia Eco Tour routes. Inset map shows Argentina’s location.
    Argentina • South America • Buenos Aires • El Calafate • Patagonia • Los Glaciares National Park
  • Three guanacos stand in a grassy field with mountains in the background under a blue sky, showcasing the natural beauty often experienced on Southern Patagonia tours.
    Map of southern Chile highlighting a Patagonia travel route from Punta Arenas to Puerto Natales, Seno Otway, Balmaceda Glacier, and Torres del Paine. Inset shows Southern Patagonia’s location in South America. Circles mark stops; lines indicate excursions and overnights.
    Cave of the Hands • Chile • South America • Patagonia • Santiago • Torres del Paine
  • A large white building with towers and arches stands behind a green vineyard, typical of wineries in Chile, with tall trees and mountains in the background under a partly cloudy sky.
    Map of southern South America highlighting Chile, Argentina, Uruguay, and Brazil. Travel route marked by planes and lines connects cities, with icons for overnights, excursions, and wineries. Inset map shows the region’s location.
    Argentina • Brazil • Chile • Uruguay • South America • Buenos Aires • Mendoza • Rio de Janeiro • Santiago
  • Aerial view of large, powerful waterfalls cascading over cliffs surrounded by lush green forest, with mist rising from the water and a wide river flowing through the jungle landscape—nature’s beauty rivaling pristine beaches and tranquil lakes.
    Popular
    Los Glaciares National Park • Perito Moreno Glacier • Argentina • Buenos Aires • El Calafate • Ushuaia • Iguazu Falls
  • Scenic view of a blue lake surrounded by lush green forests, yellow wildflowers in the foreground, and distant snow-capped mountains beneath a partly cloudy blue sky—an unforgettable highlight of Argentina travel.
    A map of Argentina highlights the best of Argentina travel routes connecting Buenos Aires, Iguassu Falls, Mendoza, Puerto Madryn, Bariloche, El Calafate, and Ushuaia, with icons for flights, overnights, and optional destinations.
    Argentina • Buenos Aires • Bariloche • El Calafate • Ushuaia
  • A marina with sailboats docked, palm trees lining the waterfront, and several birds floating on the calm water. Buildings are visible in the background under a partly cloudy sky in Punta del Este, Uruguay.
    Map showing a travel route in Uruguay from Colonia to Cabo Polonio, passing through Montevideo and Punta del Este. Blue dots indicate overnight stays; pink dots mark optional tours. Inset locates Uruguay within South America.
    Uruguay • Buenos Aires • Montevideo • Punta del Este • Colonia del Sacramento
  • White, Gaudí-inspired Casapueblo building with curved walls and towers overlooks the blue sea in Punta Ballena, Uruguay—a stunning stop on any coast tour. A tree and stone path are in the foreground under a clear sky.
    A map of South America showing a Coast to Coast Tour route through Peru, Bolivia, Argentina, and Uruguay. Cities, excursions, overnights, flight and ship paths, and country borders are labeled. An inset map shows the region’s global location.
    Multi-Country • Lima • Cusco • Machu Picchu • Lake Titicaca • La Paz • Salar de Uyuni • Argentina • Bolivia • Peru • Uruguay • South America • Buenos Aires • Iguazu Falls • Salta • Quebrada de Humahuaca

Create Your Own Custom Tour

Click or Tap your preferences: Destinations & Activities. Be as specific or general as you like – or click Help Me Decide! We’ll spice it with hidden gems & personal tips to create your perfect trip. Need assistance? Contact an expert at +1 (888) 900-5060

Step 1 of 6 - Destinations

Choose Destinations
Destinations
Amazon Interests
Argentina Interests
Bolivia Interests
Brazil Interests
Chile Interests
Colombia & Panama Interests
Ecuador & Galápagos Interests
Paraguay & Uruguay Interests
Patagonia & Antarctica Interests
Peru & Machu Picchu Interests
Guianas Interests
Choose Interests
Get to Know South America and...

Plan Your South America Trip

Get to Know Us

Why Plan Your Journey with Us

A vibrant collage highlighting south america tours: a woman with a llama, Rio de Janeiro’s Christ the Redeemer, a boat on turquoise Patagonian waters, Iguazu Falls, and two smiling people leaning from a green train.
With decades of experience crafting journeys across South America, our team combines local expertise, trusted partnerships, and personalized planning to design unforgettable trips. From your first conversation to your return home, we handle the details so you can travel with confidence.

South America Travel Info

Planning a trip to South America? Explore essential travel info including via requirements, safety tips, weather, money, and more so you can focus on designing the perfect adventure!

Icon
South America Hotels & Resorts
Icon
South America Articles
Icon
South America Staying Healthy
Icon
Internet & Calling in South America
Icon
South America Travel Insurance
Icon
South America Packing List
Icon
Money in South America
Icon
South America Visa Requirements
Icon
South America Flights
Icon
Weather in South America
Icon
Languages of South America
Icon
South America Food & Drink
Icon
Safety in South America
Your Experts in South America!

Let’s Design Your Perfect South America Trip

Four people work at standing desks with headsets and computers in a bright office. A colorful “SouthAmerica.travel” banner and destination photos are displayed in the background.
We Love to Talk About South America Trip Ideas!

Thinking of traveling to South America? We take your South American travel dream and make it a reality. Every fully custom South America trip is planned by your own expert personal Travel Consultant.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.
Full Name*

We ❤️ to talk! A brief chat with your personal Travel Consultant helps us create your perfect trip!

South America Travel Guide PDF Cover Page.

South America Travel Guide

Our favorite South America tour ideas featuring the best destinations & activities designed to inspire…

Get your FREE South America Guide Now!

Name(Required)